Wednesday, 23 September 2026
379 articles · times in UTC
Nature News · 00:00
Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11059-5 ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-like states and markedly enhances antiviral and antitumou…
Nature News · 00:00
Banking records reveal characteristics of financial abuse ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11049-7 An analysis of UK banking data reveals that people who reported being victim-survivors of financial abuse experience worse financial outcomes compared with a control group.
Nature News · 00:00
Hepatocytes promote liver metastasis of pancreatic cancer by providing serine ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11051-z Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth and survival.
Nature News · 00:00
A design approach for bitopic kinase inhibitors ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11056-8 Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and EGFR kinases, including an ABL1 inhibitor with enhanced activity against resistance mutations and reduced off-ta…
Nature News · 00:00
What is needed for regenerative medicine to flourish? ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02854-1 Although the field’s breakthrough research has the potential to save lives, it requires a more in-depth and equitable foundation of research.
Nature News · 00:00
A guide to the Nature Index ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02858-x A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.
Nature News · 00:00
‘Remarkably encouraging’: stem-cell treatments for autoimmune diseases enter new phase ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02855-0 Scientists are working to transform the body’s most versatile cells into viable therapies, but the challenge of immunosuppression looms.
Nature News · 00:00
Lack of female researchers and participants in regenerative-medicine research holds everyone back ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02857-y The field will not reach its potential using data sets in which women and non-binary people are not fully represented.
Nature News · 00:00
Competition heats up in the regenerative-medicine ranks ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02856-z The United States leads, but China poses strong competition, according to the latest Nature Index data.
Nature News · 00:00
Author Correction: Large recoverable elastic energy in chiral metamaterials via twist buckling ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11189-w Author Correction: Large recoverable elastic energy in chiral metamaterials via twist buckling
Nature News · 00:00
A methanogen hydrolase reveals the structure of archaeal peptidoglycan ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11028-y ArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl hydrolase specific for cleaving the cell wall of methanogens, revealing an unsuspected chemical structure of…
Nature News · 00:00
Reference genomes and fossils revise bat family phylogeny and biogeography ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11007-3 An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
Nature News · 00:00
mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11054-w Reactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a primary driver of pathogenesis and highlighting the astrocytes as potential therapeutic targets for tuberous…
Nature News · 00:00
Anomalous metal and superconducting phases in rhombohedral graphene ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11033-1 Observations of rhombohedral graphene on a WSe2 substrate at varying temperature, magnetic field and current indicate the presence of regions of gate space with zero-resistance superconductivity alongside others with finite saturation resi…
Nature News · 00:00
In praise of human teachers: universities must resist outsourcing everything to AI ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02949-9 An AI revolution is sweeping through education. But teachers who can convey the excitement of thinking and learning are irreplaceable.
Nature News · 00:00
How to stay smart in the age of AI: the science of critical thinking ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02930-6 There is growing concern that AI can blunt memory and reasoning. But science shows ways to keep the brain sharp.
Nature News · 00:00
Huge hoard of metal bars hints at vast Iron Age trade ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02986-4 One-tonne cache of iron is the largest ever found — and enough to make roughly 500 swords.
Nature News · 00:00
How do I rekindle my motivation for earning my PhD? ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02563-9 An early-career researcher has hit a roadblock. Here’s how they can persevere in their studies.
Nature News · 00:00
The courier ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02861-2 A special delivery.
Nature News · 00:00
Lsp2 links early-life diet to adult translation and lifespan in Drosophila ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11031-3 Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the effects of early-life protein restriction.
Nature News · 00:00
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11029-x In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of TOP mRNAs and improved longevity.
Nature News · 00:00
TRAM promotes Toll-like-receptor-free myddosome signal transduction ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11052-y TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.
Nature News · 00:00
Stacking-induced direct band gap in CVD-grown 1H MoS 2 bilayers ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11069-3 Atomically aligned 1H bilayer MoS2 exhibits a direct band gap, enhanced excitonic emission and stronger valley polarization, establishing its potential for advanced optoelectronic and valleytronic applications.
Nature News · 00:00
Agricultural liming is a carbon sink in the Mississippi River Basin ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11040-2 Century-scale records of agricultural liming and anthropogenic acidity inputs for the Mississippi River Basin show that agricultural liming has acted as a net carbon sink over the past century.
Nature News · 00:00
Bank accounts reveal the fingerprints of abusive financial control ↗Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-03021-2 Analysis of anonymized banking data could help inform strategies to support victim-survivors of financial abuse — plus, how opposing forces within the Earth can alter the length of a day.
Nature News · 00:00
The gene-regulatory evolution of the human skeleton ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11053-x Massively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements (CREs), revealing how differences in CREs have shaped the composition of human skeletal tissue.
Nature News · 00:00
Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11169-0 Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes
Nature News · 00:00
Lifespan single-cell transcriptomic atlas of the human prefrontal cortex ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10271-7 The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in late adu…
Nature News · 00:00
The anthropogenic fingerprint on emerging infectious diseases ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11058-6 Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data on outbreaks are currently limited by inequalities in…
Nature News · 00:00
Gravitational torque drives multidecadal variations in length of day ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10999-2 Multidecadal fluctuations in Earth’s length of day are shown to be driven by gravitational torque and resisted by electromagnetic and topographic forces, improving our understanding of the material properties and dynamics of Earth’s deep i…
Nature News · 00:00
Single-nucleus transcriptome-wide association study of human brain disorders ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10836-6 Single-nucleus transcriptomics across diverse populations is used to explore how genetic risk for brain disorders affects specific cell types, revealing previously hidden gene–trait associations and conserved, cell-type-specific mechanisms.
Nature News · 00:00
Lu + optical frequency references with accuracy verified at the 19th digit ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11072-8 Two independent 176Lu+ single-ion optical clocks achieve fractional frequency uncertainties near 10−19 and agree at 5.7 × 10−19, advancing precision timekeeping.
Nature News · 00:00
Sequence-encoded hexagonal lattices in multichannel peptide nanofibrils ↗Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11016-2 Nine-residue peptides can encode discrete interaction motifs that direct the formation of hexagonal pores, which hierarchically tile into laterally expandable multichannel nanofibrils with defined topology.